Alveolar macrophages from patients with bronchogenic carcinoma and sarcoidosis similarly express monocyte antigens
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چکیده
منابع مشابه
Human alveolar macrophages express Ia-like antigens.
Monoclonal antibody to la-like antigens was used to demonstrate the presence of these antigens on human alveolar macrophages. Immunoprecipitation demonstrated the 27,000 and 34,000 molecular weight peaks that correspond to the la-like antigen subunits. Immunofluorescence confirmed the presence of la-like antigens on alveolar macrophages but not on other bronchoalveolar cells. The presence of al...
متن کاملAltered immunological reactivity in alveolar macrophages from patients with sarcoidosis.
Lung macrophages may play an important role in the pathogenesis of pulmonary sarcoidosis. In this study, the ability of pulmonary macrophages and blood monocytes from sarcoidosis patients, normal controls and disease controls to provide the accessory signal necessary for the concanavalin A-induced activation of normal blood T cells was examined. Blood monocytes from all groups supplied a signif...
متن کاملRelease of prostaglandin E2 and leukotriene B4 by alveolar macrophages from patients with sarcoidosis.
BACKGROUND Mediators released by alveolar macrophages, as well as by T cells, play an important part in modulating local immune processes in sarcoidosis. Among alveolar macrophage secretory products, arachidonic acid metabolites are known to regulate inflammatory and immune reactions. It has been suggested that cyclo-oxygenase and lipoxygenase pathway metabolites of arachidonic acid modulate th...
متن کاملDiminished activity of tartrate resistant acid phosphatase in alveolar macrophages from patients with active sarcoidosis.
Alveolar macrophages differ from their percursors in blood, monocytes, by expressing strong activity of the tartrate resistant variant of acid phosphatase (TAcP). A study was carried out to analyse the expression of this enzyme cytochemical marker by alveolar macrophages from bronchoalveolar lavage cells from 34 patients with sarcoidosis and 12 control subjects. Alveolar macrophages from contro...
متن کاملPulmonary Alveolar Macrophages from Patients with Active Sarcoidosis Express Type IV Collagenolytic Proteinase An Enzymatic Mechanism for Influx of Mononuclear Phagocytes
Alveolar macrophages (AMs) recovered from the bronchoalveolar lavage (BAL) of44 patients with sarcoidosis were evaluated for their ability to release type IV collagenolytic metalloproteinase (IV-Cm..). This enzyme, which is produced by peripheral blood monocytes (PBMs) but not by tissue macrophages, degrades type IV collagen, the major structural component of vessel wall basement membranes, and...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2008
ISSN: 0009-9104
DOI: 10.1111/j.1365-2249.1991.tb05791.x